A single-center, retrospective, observational study was conducted at Hankou Hospital, which is one of the hospitals designated to treat COVID-19 pneumonia patients in Wuhan, China. The criteria for suspected and confirmed cases of COVID-19 were based on the criteria previously established by the WHO.
A total of 274 patients, 75 with hypertension and 199 without hypertension ―all them patients with clinically confirmed COVID-19 who were admitted between January 5 and March 8, 2020―, were included in the analysis.
Authors obtained epidemiological, demographic, clinical, laboratory, management, and outcome data from patients’ medical records using standardized data collection forms. Clinical outcomes were followed up to March 8, 2020. To analyze the relationship between stage of hypertension and clinical outcome, a minimum follow-up time of 14 days was required, including follow-up of patients who were discharged before March 8, 2020. If data were missing from the records or clarification was needed, the researchers also directly communicated with patients or their families to ascertain epidemiological and symptom data.
The primary variable of interest was 28-day mortality (calculated from the day of admission). Secondary outcome variables included the severity of pneumonia, length of hospital stay, discharge rate from hospital, and hospitalization rate.
The study points to patients with hypertension were older and were more likely to have pre-existing comorbidities, including chronic renal insufficiency, cardiovascular disease, diabetes mellitus, and cerebrovascular disease than patients without hypertension. Besides, patients with hypertension tended to have higher positive COVID-19 Polymerase Chain Reaction (PCR) detection rates. Moreover, patients with hypertension who had previously taken ACEI/ARB drugs for antihypertensive treatment have an increased tendency to develop severe pneumonia after infection with SARS-COV-2.
Link to the paper: https://doi.org/10.1101/2020.04.06.20054825
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